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CARR Biosystems

Scalable Cell Harvest and Wash for Allogeneic Manufacturing

Single-use UniFuge® centrifugation, delivered in partnership with CARR Biosystems

Gowned Made Scientific operator loading sample tubes into a centrifuge in a GMP cleanroom
PartnershipTechnology and supply
PlatformUniFuge® single-use centrifugation
Initial focusMSC and feeder cell processes
SitesPrinceton, NJ and East Norriton, PA

Integrated Cell Separation, from Process Development to Commercial Supply

One separation step from milliliters to more than 2,000 liters

Made Scientific and CARR Biosystems have partnered to bring CARR's UniFuge® single-use centrifugation systems into Made Scientific's GMP operations in Princeton, New Jersey and East Norriton, Pennsylvania. UniFuge serves as a closed, automated cell harvest, wash, and concentration step for 3D and large-scale manufacturing of mesenchymal stem cells (MSCs) and feeder cells.

  • Why it matters: As allogeneic programs scale, harvest and wash is where large-volume processes are most often constrained and where significant yields can be lost
  • What's different: Low-shear tubular bowl centrifugation supports cell concentration, washing, media exchange, harvest, and formulation while maintaining high cell viability and product recovery
  • Where we are: Made Scientific is deploying multiple UniFuge systems across both facilities and equipping East Norriton with scalable 3D bioreactor platforms of up to 200 liters
  • What it enables: Process development at smaller scale can translate to larger volumes on the same technology, supporting comparability and reducing scale-up risk

“Made Scientific's expanding clinical-to-commercial footprint make it an ideal partner for scalable, single-use cell processing. Their team's manufacturing expertise and focus on scale-up align closely with how we designed the UniFuge platform. Together, we can help cell therapy developers bring processes from the clinic to commercial supply with confidence.”

Joel Williams, President of CARR Biosystems

How UniFuge Fits into Cell Therapy Manufacturing

Initial focus: MSC and feeder cell processes

UniFuge gives Made Scientific's 3D bioreactor platforms a closed, automated separation step that carries from process development into GMP production.

  • Small to large scale: joint development studies on CARR's benchtop UFMini® system generate small-scale data that carries forward to larger volumes
  • One platform family: single-use systems that span process volumes from milliliters to more than 2,000 liters
  • Built for GMP: automated operation, rapid changeover, and a 21 CFR Part 11-compliant data trail

What Clients Can Expect

A closed, automated separation step

Harvest, wash, concentration, and formulation run on a single-use, closed system, alongside the closed and automated technologies Made Scientific already operates.

High viability and product recovery

Low-shear tubular bowl centrifugation is designed to maintain high cell viability and product recovery at large volumes, where harvest and wash most often limit yield.

Scale-up on the same technology

Process development at smaller scale translates to larger volumes on the same platform, which supports comparability and helps programs advance as demand grows.

A preferred CDMO for UniFuge programs

Made Scientific serves as a preferred CDMO for CARR customers evaluating the platform, and RoosterBio MSC and EV programs that use UniFuge transfer into Made Scientific's GMP operations on the same technology.

Why Partner with Made Scientific + CARR Biosystems

CARR Biosystems UniFuge®: single-use cell processing built for scale

  • Low-shear tubular bowl centrifugation for concentration, washing, media exchange, harvest, and formulation
  • A single-use family from milliliters to more than 2,000 liters
  • Automated operation with rapid changeover
  • A 21 CFR Part 11-compliant data trail

Integrated CDMO services, scale-ready by design

  • GMP manufacturing at Made Scientific's facilities in Princeton, New Jersey and East Norriton, Pennsylvania
  • Scalable 3D bioreactor platforms of up to 200 liters in East Norriton
  • A broad portfolio of closed and automated technologies already in operation
  • Support from development through commercial supply

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Made Scientific cleanroom operators working along a GMP corridor
Made Scientific - Interactive Background

Scale Your Allogeneic Program

Tell us where your MSC or feeder cell process stands and where it needs to scale. We’ll map a path from process development to GMP supply on UniFuge.